Answer to Question 1
1
Rationale 1: Bisphosphonates are drugs of choice for the pharmacotherapy of Paget disease. Therapy is usually cyclic: Bisphosphonates are administered until serum alkaline phosphatase levels return to normal; then a drug-free period of several months follows. When serum alkaline phosphatase levels become elevated, therapy is begun again.
Rationale 2: Selective estrogen-receptor modulators (SERMs) are used in the treatment of osteoporosis.
Rationale 3: Hormone replacement therapy (HT) is used for menopause.
Rationale 4: NSAIDs areused for a variety of inflammatory conditions.
Global Rationale: Bisphosphonates are drugs of choice for the pharmacotherapy of Paget disease. Therapy is usually cyclic: Bisphosphonates are administered until serum alkaline phosphatase levels return to normal; then a drug-free period of several months follows. When serum alkaline phosphatase levels become elevated, therapy is begun again.
Answer to Question 2
1, 2, 3
Rationale 1: Rituximab (Rituxan) is used to treat rheumatoid arthritis.
Rationale 2: Leflunomide (Arava) is used to treat rheumatoid arthritis.
Rationale 3: Sulfasalazine (Azulfidine) is used to treat rheumatoid arthritis.
Rationale 4: Tizanidine (Zanaflex) is not used to treat rheumatoid arthritis.
Rationale 5: Ibuprofen (Advil) is not used to treat rheumatoid arthritis.
Global Rationale: Rituximab (Rituxan), Leflunomide (Arava),and Sulfasalazine (Azulfidine) are used to treat rheumatoid arthritis. Tizanidine (Zanaflex) is not used to treat rheumatoid arthritis. Ibuprofen (Advil) is not used to treat rheumatoid arthritis.
Parkinson’s Disease
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