Author Question: Folic acid analogs can be toxic to normal cells as well as to cancer cells. Which drug will the ... (Read 57 times)

elizabeth18 · **on:** Jul 23, 2018

Folic acid analogs can be toxic to normal cells as well as to cancer cells. Which drug will the nurse administer following the administration of methotrexate to rescue the normal cells, causing them to be able to continue replication and devel

1. Leucovorin
2. Iron therapy
3. Immunoglobulin
4. Vitamin B12

Question 2

When a client taking methotrexate notifies the nurse of a sudden onset of a rash, the nurse is alerted to what life-threatening adverse effect associated with methotrexate?

1. Peptic ulcer
2. StevensJohnson syndrome
3. Pancreatitis
4. Myocardial infarction

apple · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

Correct Answer: 1
Rationale 1: Leucovorin is given to rescue normal cells during methotrexate administration.
Rationale 2: Iron therapy does not rescue normal cells from folic acid analogs.
Rationale 3: Immunoglobulin does not rescue normal cells from folic acid analogs.
Rationale 4: Vitamin B12 does not rescue normal cells from folic acid analogs.
Global Rationale: Leucovorin, or folinic acid, is a reduced form of folic acid that is able to enter normal cells but not cancer cells. It is given to rescue normal cells during methotrexate administration. The other drugs are not used for this purpose.

Answer to Question 2

Correct Answer: 2
Rationale 1: This is potentially life-threatening, but not associated with a rash.
Rationale 2: This is the correct answer.
Rationale 3: This is potentially life-threatening, but not associated with a rash.
Rationale 4: This is life-threatening, but not associated with a rash.
Global Rationale: Severe, sometimes fatal, dermatologic reactions such as toxic epidermal necrolysis and SJS have been reported in those receiving methotrexate. The other conditions may be life-threatening, but are not associated with rash.