Author Question: Which are physiologic changes during pregnancy that affect drug absorption, metabolism, ... (Read 23 times)

jace · **on:** Jul 23, 2018

Which are physiologic changes during pregnancy that affect drug absorption, metabolism, distribution, and excretion? (Select all that apply.)

a. Circulating steroid hormones
b. Decreased gastrointestinal motility
c. Decreased renal perfusion
d. Increased maternal circulatory blood volume
e. Poor sleep and fatigue
f. Rapid respiratory rate

Question 2

The nurse is caring for a woman who is in labor and has a blood pressure of 180/98 mm Hg with proteinuria of 400 mg/24 hours. The woman is receiving magnesium sulfate.

The woman becomes lethargic with slurring of her speech and decreased muscle tone. Her serum magnesium sulfate level is 11 mEq/L. The nurse recognizes which condition in this patient?
a. Abruptio placenta
b. Hypertensive crisis
c. Impending eclampsia
d. Magnesium toxicity

shoemake · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

ANS: A, B, D
Steroid hormones, decreased GI motility, and increased blood volume all affect maternal drug effectiveness. Renal perfusion is increased during pregnancy. Poor sleep does not alter drug effectiveness. Rapid respiratory rate does not necessarily occur.

Answer to Question 2

ANS: D
Patients receiving magnesium sulfate can develop toxicity, evidenced by lethargy, slurred speech, and decreased muscle tone. A level greater than 10 mEq/L indicates toxicity. Patients with severe eclampsia will have marked elevation of blood pressure and seizures.