Which are guidelines for selecting chemotherapeutic agents to use ...

[tatyanajohnson]

Which are guidelines for selecting chemotherapeutic agents to use in combination therapy? (Select all that apply.)
 
  a. Drugs used should have different me-chanisms.
  b. Each drug should be delivered by differ-ent routes.
  c. Each drug should be effective.
  d. Each drug should have different dosing schedules.
  e. Toxicities should be minimally overlap-ping.

Question 2

What contributes to drug resistance to chemotherapeutic agents? (Select all that apply.)
 
  a. Cellular production of P-glycoprotein
  b. Creation of selection pressure by drugs
  c. Drug-induced cellular mutation
  d. Increased drug uptake by tumor cells
  e. Reduced target molecule sensitivity

Question 3

A patient has just been diagnosed with cancer and will begin chemotherapy. The patient asks the nurse about the possibility of nausea and vomiting. The nurse will tell the patient that:
 
  a. nausea and vomiting can be avoided by having a snack before chemotherapy.
  b. nausea and vomiting are common side effects and will abate over time.
  c. nausea and vomiting are common and will be treated with antiemetics when they oc-cur.
  d. the provider will order drugs to help pre-vent nausea and vomiting before each dose.

[amandalm]

Answer to Question 1

A, C, E
When selecting drugs for combination therapy, each drug should be effective by itself and should have a different mechanism of action. The drugs should have minimally overlapping toxicities. The routes and the dosing schedules are not considerations.

Answer to Question 2

wohoo thank youuu.

Answer to Question 3

D
Nausea and vomiting are common but can be reduced by premedication with antiemetics. Having a snack before dosing is not effective. This side effect will not abate over time. Antiemetics are most effective when given before dosing, not as needed.

[tatyanajohnson]

Thanks

[amandalm]

Welcome