Select the metabolic pathway that converts toxic hydrogen ...

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Select the metabolic pathway that converts toxic hydrogen peroxide produced by oxidant drugs to water:
 
  a. Embden-Meyerhof pathway (EMP)
  b. 2,3-Biphosphoglycerate (2,3-BPG)
  c. Methemoglobin reductase reaction
  d. Hexose monophosphate pathway

Question 2

What is the normal life span of a red cell in circulation?
 
  a. 2 Weeks
  b. 90 Days
  c. 120 Days
  d. 6 Months

[bfulkerson77]

Answer to Question 1

ANS: D
Hydrogen peroxide is an oxidant and is detoxified via the hexose monophosphate pathway using reduced glutathione. The EMP generates energy in the form of ATP; the 2,3-BPG pathway is a shunt off of the EMP that is important for the reversible binding of oxygen. Methemoglobin reductase is an enzyme that reduces the oxidized form of hemoglobin, called methemoglobin, to its reduced functional form.

Answer to Question 2

ANS: C
The normal red cell survives 120 days in circulation after its release from the bone marrow. By that time, changes that have occurred both internally and on the RBC membrane result in its phagocytosis and thus removal by splenic macrophages.

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Correct answers!

[bfulkerson77]

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