A 45-year-old female was evaluated by her physician because she had unexplained bruising on her upper torso. Patient history was unremarkable. Physical examination revealed a palpable liver and spleen. CBC results revealed:
WBC count: 12 x 109/L
Hb: 8.7 g/dL
Hct: 25
Normal indices
PLT count: 5 x 109/L
Differential: 80 blasts and 15 promyelocytes present
Bone marrow findings: hypercellular marrow with 47 myeloblasts present. Nucleated erythroblasts: 22; promyelocytes: 28; megakaryopoiesis appears normal.
Cytogenetic analysis: t(15, 17) present.
Flow cytometry has also been ordered on this patient. Which of the following markers will stain positive in this case?
a. HLA-DR
b. CD35
c. CD33
d. CD8
Question 2
A patient presents with a morphological smear examination revealing >20 blasts with prominent granules and Auer rods, MPO, and SBB positive. A 25 monocyte count was seen in the peripheral smear.There were no recurrent cytogenetic abnormalities observ
Under which classification of acute leukemia, not otherwise specific, does this diagnosis fall?
a. Acute myeloblastic leukemia without maturation
b. Acute myelomonocytic leukemia
c. Acute erythroid leukemia
d. Acute panmyelosis with myelofibrosis
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