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Author Question: Explain the pathophysiology of MDS. What will be an ideal ... (Read 71 times)

bcretired

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on: Jun 25, 2018
Explain the pathophysiology of MDS.
 
  What will be an ideal response?

Question 2

Give at least five morphologic indicators of dyserythropoiesis.
 
  What will be an ideal response?


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Anonymous

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Reply #1 on: Jun 25, 2018
Answer to Question 1

Answer: MDS results from persistent gradual expansion of abnormal hematopoietic stem cells that leads to ineffective hematopoiesis. Chromosomal abnormalities accompany the MDS pathogenesis >50 of the time.

Answer to Question 2

Answer: Evidence of dyserythropoiesis in peripheral circulation includes anemia, macrocytosis, oval macrocytes, dimorphism, Howell-Jolly bodies, NRBCs, basophilic stippling, anisocytosis, poikilocytosis, and reticulocytopenia. Evidence of dyserythropoiesis in the bone marrow includes megaloblastoid erythropoiesis, nuclear fragmentation and budding, karyorrhexis, multinucleation, defective hemoglobinization, vacuolization, and ringed sideroblasts.


bcretired

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Reply #2 on: Jun 25, 2018
Correct answers!


Anonymous

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Reply #3 on: Jun 25, 2018
Great! Please up vote :D


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