Author Question: Which of the following statements most accurately describes the action of colestipol (Colestid) in ... (Read 103 times)

ssal · **on:** Jul 23, 2018

Which of the following statements most accurately describes the action of colestipol (Colestid) in the reduction of serum cholesterol levels?

a. It prevents synthesis of cholesterol by the liver.
b. It inhibits the secretion of cholesterol by the liver into bile salts.
c. It prevents the uptake of excess cholesterol from the blood stream by the liver.
d. It binds to bile salts in the gastrointestinal (GI) tract, preventing their reabsorp-tion.

Question 2

Which of the following variables must be considered when the decision to start antihypertensive drug therapy is being initiated? Select all that apply.

a. Stage and degree of blood pressure elevation
b. Adherence to therapy with once-daily dosing
c. Presence of clinical cardiovascular or other risk factors
d. Presence of end-organ damage
e. Safety profile of the specific drug or drugs
f. Reduced risk of sudden death, heart attack, and stroke caused by abrupt increases in blood pressure after arising

shewald78 · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

ANS: D
Bile acid resins such as colestipol are anion-exchange resins that reduce low-density lipoprotein (LDL) levels by binding bile salts in exchange for chloride ions. These drugs form an insoluble complex with bile acids in the intestine. The bile acid-drug complex prevents the reabsorption of the bile acids, thus increasing their elimination. In an attempt to compensate for the loss of bile salts, the liver raises the rate of bile acid synthesis.

Answer to Question 2

ANS: A, C, D, E
The decision to start antihypertensive drug therapy requires careful consideration of several fac-tors including the following:
Stage and degree of blood pressure elevation
Presence of clinical cardiovascular or other risk factors
Presence of end-organ damage
Safety profile of the specific drug or drugs
Efficacy and convenience of specific drug or drugs
Potential for drug interactions
Treatment costs, including laboratory testing, and follow-up visits to health care provider.