What is the drug of choice for the pharmacotherapy of Paget ...

[cartlidgeashley]

What is the drug of choice for the pharmacotherapy of Paget disease?
 
  1. Bisphosphonates
  2. Selective estrogen-receptor modulators (SERMs)
  3. Hormone replacement therapy (HRT)
  4. NSAIDs

Question 2

Which medications are used to treat rheumatoid arthritis?(Select all that apply.)
 
  1. Rituximab (Rituxan)
  2. Leflunomide (Arava)
  3. Sulfasalazine (Azulfidine)
  4. Tizanidine (Zanaflex)
  5. Ibuprofen (Advil)

[todom5090]

Answer to Question 1

1

Rationale 1: Bisphosphonates are drugs of choice for the pharmacotherapy of Paget disease. Therapy is usually cyclic: Bisphosphonates are administered until serum alkaline phosphatase levels return to normal; then a drug-free period of several months follows. When serum alkaline phosphatase levels become elevated, therapy is begun again.
Rationale 2: Selective estrogen-receptor modulators (SERMs) are used in the treatment of osteoporosis.
Rationale 3: Hormone replacement therapy (HT) is used for menopause.
Rationale 4: NSAIDs areused for a variety of inflammatory conditions.

Global Rationale: Bisphosphonates are drugs of choice for the pharmacotherapy of Paget disease. Therapy is usually cyclic: Bisphosphonates are administered until serum alkaline phosphatase levels return to normal; then a drug-free period of several months follows. When serum alkaline phosphatase levels become elevated, therapy is begun again.

Answer to Question 2

1, 2, 3

Rationale 1: Rituximab (Rituxan) is used to treat rheumatoid arthritis.
Rationale 2: Leflunomide (Arava) is used to treat rheumatoid arthritis.
Rationale 3: Sulfasalazine (Azulfidine) is used to treat rheumatoid arthritis.
Rationale 4: Tizanidine (Zanaflex) is not used to treat rheumatoid arthritis.
Rationale 5: Ibuprofen (Advil) is not used to treat rheumatoid arthritis.

Global Rationale: Rituximab (Rituxan), Leflunomide (Arava),and Sulfasalazine (Azulfidine) are used to treat rheumatoid arthritis. Tizanidine (Zanaflex) is not used to treat rheumatoid arthritis. Ibuprofen (Advil) is not used to treat rheumatoid arthritis.

[cartlidgeashley]

TY

[todom5090]

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