Author Question: Cyclophosphamide (Cytoxan) has been prescribed orally for a client. What is the rationale for why ... (Read 24 times)

mmm · **on:** Jul 23, 2018

Cyclophosphamide (Cytoxan) has been prescribed orally for a client. What is the rationale for why this medication has been prescribed orally for this client?

1. There are few side effects when given orally.
2. It is only available parenterally.
3. It is one of only a few anticancer drugs that are well absorbed when given orally.
4. The client has a new diagnosis of cancer.

Question 2

The nurse is caring for a client who experiences nausea and vomiting with each treatment of chemotherapy. What should the nurse advise the client to do to decrease nausea and vomiting?

1. Do not eat for 12 hours before treatment
2. Increase food intake
3. Take antiemetic medications prior to treatment
4. Decrease water intake

mjbamaung · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

3

Rationale 1: There are many side effects from this treatment.
Rationale 2: Cyclophosphamide can be given PO and IV but the drug is well absorbed when given orally.
Rationale 3: Cyclophosphamide is one of only a few anticancer drugs that are well absorbed when given orally.
Rationale 4: Cyclophosphamide is well absorbed when given orally.

Global Rationale: Cyclophosphamide is one of only a few anticancer drugs that are well absorbed when given orally. There are many side effects from this treatment. Cyclophosphamide can be given PO and IV.

Answer to Question 2

3

Rationale 1:Nausea and vomiting are caused by the medulla, and avoiding food will not eliminate nausea and vomiting.
Rationale 2:The client needs to take an antiemetic to stop vomiting.
Rationale 3: The vomiting center in the medulla is triggered by many antineoplastics, resulting in severe nausea and vomiting. Vomiting is often so severe that patients may be treated with antiemetic drugs such as prochlorperazine (Compazine) or ondansetron (Zofran) before beginning antineoplastic therapy.
Rationale 4:Decrease water intake is incorrect because this will lead to dehydration and affect the nausea.

Global Rationale: The vomiting center in the medulla is triggered by many antineoplastics, resulting in severe nausea and vomiting. Vomiting is often so severe that patients may be treated with antiemetic drugs such as prochlorperazine (Compazine) or ondansetron (Zofran) before beginning antineoplastic therapy.