Answer to Question 1
Correct Answer: 1,2
Rationale 1: This medication can be administered by mouth in the treatment of a UTI.
Rationale 2: This medication can be administered by the intravenous route in the treatment of a UTI.
Rationale 3: This medication cannot be administered by the intramuscular route in the treatment of a UTI.
Rationale 4: This medication cannot be administered by the subcutaneous route in the treatment of a UTI.
Rationale 5: This medication cannot be administered topically in the treatment of a UTI.
Global Rationale: This medication is administered only by the oral and intravenous routes.
Answer to Question 2
Correct Answer: 1,2
Rationale 1: Trimethoprim-sulfamethoxazole (TMP-SMZ) is a safe and effective treatment for infants with a urinary tract infection.
Rationale 2: Nitrofurantoin (Furadantin) is a safe and effective treatment for infants with a urinary tract infection.
Rationale 3: The safety and efficacy of fosfomycin (Monurol) have not been established in children younger than 12 years old.
Rationale 4: Norfloxacin (Noroxin) is a fluoroquinolone and as such is contraindicated for children under age 18 because these drugs have been found to affect cartilage development.
Rationale 5: Levofloxacin (Levaquin) is a fluoroquinolone and as such is contraindicated for children under age 18 because these drugs have been found to affect cartilage development.
Global Rationale: TMP-SMZ and nitrofurantoin are effective in children. However, fluoroquinolones are contraindicated in children under age 18 because these drugs have been found to affect cartilage development. The safety and efficacy of fosfomycin has not been established in children younger than 12 years old.