Author Question: A male client of African descent has been prescribed sulfamethoxazole with trimethoprim (Bactrim), a ... (Read 83 times)

Kikoku · **on:** Jul 23, 2018

A male client of African descent has been prescribed sulfamethoxazole with trimethoprim (Bactrim), a sulfonamide anti-infective, for a bacterial infection.

When the client arrives in the emergency department, the nurse should place priority on which assessment?
1. Urinary output
2. Level of red blood cells (RBCs)
3. Liver function tests
4. Renal function tests

Question 2

The student nurse has been reading about the Human Genome Project, and asks the nursing instructor how it will affect future pharmacological therapies. Which response by the nurse is the most appropriate?

1. It will help prevent disease through gene manipulation, but will not impact drugs.
2. We will be able to alter genes, so we will not need drugs,
3. We will be able to standardize drug doses to make prescribing easier.
4. It will help to individualize drug therapy for people in a more effective way.

batool · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

Correct Answer: 2
Rationale 1: Urinary output is not the priority assessment based on the information provided.
Rationale 2: Males of African descent are more likely to be deficient in the enzyme G6PD, an enzyme that is essential in carbohydrate metabolism. The use of sulfonamides in this group of clients can cause an acute hemolysis of red blood cells due to the breaking chemical bonds in the hemoglobin molecule.
Rationale 3: Liver function tests are not the priority assessment based on the information provided.
Rationale 4: Renal function tests are not the priority assessment based on the information provided.
Global Rationale: Males of African descent are more likely to be deficient in the enzyme G6PD, an enzyme that is essential in carbohydrate metabolism. The use of sulfonamides in this group of clients can cause an acute hemolysis of red blood cells due to the breaking chemical bonds in the hemoglobin molecule. Urinary output is not the priority assessment based on the information provided. Liver function tests are not the priority assessment based on the information provided. Renal function tests are not the priority assessment based on the information provided.

Answer to Question 2

4. It will help to individualize drug therapy for people in a more effective way.
Correct Answer: 4
Rationale 1: Medications will be impacted greatly by this research.
Rationale 2: Altering genes to prevent illness is a possibility, but we will always need medications.
Rationale 3: Individuals will still respond differently to medications; not all drugs will have standardized doses.
Rationale 4: The goal of pharmacogenetics is to help individualize drug therapy for people in a more effective way.
Global Rationale: The goal of pharmacogenetics is to help individualize drug therapy for people in a more effective way. Medications will be impacted greatly by this research. Altering genes to prevent illness is a possibility, but we will always need medications. Individuals will still respond differently to medications; not all drugs will have standardized doses.