A drug inducing its own metabolism and subsequently having a lowered concentration and need to increase the dose to maintain a previously achieved response is an example of
a. Pharmacodynamically achieved tolerance.
b. Pharmacokinetically achieved tolerance.
c. Pharmacodynamically achieved dependence.
d. Pharmacokinetically achieved tolerance.
Question 2
The development of drug tolerance appears to be associated with all of the following but which one?
a. Altered gene expression induced by a drug.
b. The occurrence of a withdrawal syndrome from the abrupt
discontinuation of a drug.
c. Receptor down regulation.
d. Increased metabolism of a drug resulting on lowered drug
concentrations.
Potency and efficacy: (a) drug A has a higher potency than drug B; (b) drug A has a higher efficacy
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