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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
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Symptoms of kidney problems include a loss of appetite, back pain (which may be sudden and intense), chills, abdominal pain, fluid retention, nausea, the urge to urinate, vomiting, and fever.
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Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.