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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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Fewer than 10% of babies are born on their exact due dates, 50% are born within 1 week of the due date, and 90% are born within 2 weeks of the date.
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More than 150,000 Americans killed by cardiovascular disease are younger than the age of 65 years.
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On average, the stomach produces 2 L of hydrochloric acid per day.