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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
The first war in which wide-scale use of anesthetics occurred was the Civil War, and 80% of all wounds were in the extremities.
After 5 years of being diagnosed with rheumatoid arthritis, one every three patients will no longer be able to work.
Increased intake of vitamin D has been shown to reduce fractures up to 25% in older people.
After a vasectomy, it takes about 12 ejaculations to clear out sperm that were already beyond the blocked area.