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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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More than nineteen million Americans carry the factor V gene that causes blood clots, pulmonary embolism, and heart disease.
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Acetaminophen (Tylenol) in overdose can seriously damage the liver. It should never be taken by people who use alcohol heavily; it can result in severe liver damage and even a condition requiring a liver transplant.
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Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.