Unequal crossing over during prophase I can result in one sister chromosome with a deletion and another with a duplication. A mutated form of hemoglobin, known as hemoglobin Lepore, is known in the human population. Hemoglobin Lepore has a deleted set of amino acids. If it was caused by unequal crossing over, what would be an expected consequence?
A) If it is still maintained in the human population, hemoglobin Lepore must be selected for in evolution.
B) There should also be persons born with, if not living long lives with, an anti-Lepore mutation or duplication.
C) Each of the genes in the hemoglobin gene family must show the same deletion.
D) The deleted gene must have undergone exon shuffling.
E) The deleted region must be located in a different area of the individual's genome.
A molecular model showing chromosome territories in the cell nucleus of humans
Changes in chromosome number
A karyogram of the human chromosome set, showing the distinctive banding pattern of each chromosome.
DNA-sequence alignment of contigs on human chromosome 2
Partial map of disease genes on human chromosome 21
Standardized human chromosome banding patterns