A client with a history of an endocrine disorder exhibits signs ...

[berenicecastro]

A client with a history of an endocrine disorder exhibits signs and symptoms of hormone deficiency. Which of the following processes would the client's care team most likely rule out first as a contributing factor?
 
  A)
  The client's target cells lack sufficient receptors for the hormone in question.
  B)
  Hormone production is sufficient, but affinity on the part of the target cells is lacking.
  C)
  The process of down-regulation has resulted in decreased hormone sensitivity.
  D)
  Up-regulation has increased the sensitivity of the body to particular hormone levels.

Question 2

An infant born with congenital hypothyroidism and has not sought care from any health care provider is likely to develop which of the following complications? Select all that apply.
 
  A)
  Deformed joints and bone spurs
  B)
  Impaired physical growth
  C)
  Mental retardation
  D)
  Loss of fine motor control and arthritis
  E)
  Down syndrome

[bubulittle310@msn.cn]

Answer to Question 1

Ans:
D

Feedback:

Up-regulation is a response to low hormone levels in which the number of receptors increases. As such, it would not likely result in signs and symptoms of deficiency but is rather a compensatory mechanism that counters a deficiency. Insufficient numbers of receptors, low affinity, and down-regulation could all contribute to signs and symptoms of a hormone deficiency.

Answer to Question 2

Ans:
B, C

Feedback:

Thyroid hormone is essential for normal growth and brain development, almost half of which occurs during the first 6 months of life. If untreated, congenital hypothyroidism causes mental retardation and impairs physical growth. Down syndrome is a congenital birth defect and not caused by hypothyroidism.