As a follow-up to the introduction of a new medication regimen ...

[luvbio]

As a follow-up to the introduction of a new medication regimen for an older adult client, the physician is interpreting the client's recent blood work, paying particular attention to the client's serum creatinine (Cr) levels
 
  (normal range 0.6 to 1.2 mg/100 mL) and glomerular filtration rate or GFR (normal value >60 mL/minute). Which of the following lab results would be considered typical of an older adult with impaired renal function?
  A)
  Cr 1.8; GFR 66
  B)
  Cr 2.3; GFR 30
  C)
  Cr 0.5; GFR 58
  D)
  Cr 1.1; GFR 22

Question 2

As part of a screening program for prostate cancer, men at a senior citizens' center are having their blood levels of prostate-specific antigen (PSA) measured.
 
  Which of the following statements would best characterize a high positive predictive value but a low negative predictive value for this screening test?
  A)
  All of the men who had high PSA levels developed prostate cancer; several men who had low PSA levels also developed prostate cancer.
  B)
  All of the men who had low PSA levels were cancer-free; several men who had high levels also remained free of prostate cancer.
  C)
  Men who had low PSA levels also displayed false-positive results for prostate cancer; men with high levels were often falsely diagnosed with prostate cancer.
  D)
  The test displayed low sensitivity but high specificity.

[chreslie]

Answer to Question 1

Ans:
D

Feedback:

Due to decreased muscle mass and consequent decrease in creatinine production, older adults often maintain normal creatinine levels even in the presence of impaired glomerular filtration and low GFR.

Answer to Question 2

Ans:
A

Feedback:

The test's inability to rule out cancer with a low PSA level indicates a low negative predictive value. Answer B suggests a high negative predictive value, while answer C indicates a low positive predictive value. High positive predictive value is associated with high sensitivity.

[luvbio]

Correct answers!

[chreslie]

Great! Please up vote