Author Question: Patients who have a deficiency of protein C or protein S have which type of disorder? a. Bleeding ... (Read 143 times)

biggirl4568 · **on:** Jun 25, 2018

Patients who have a deficiency of protein C or protein S have which type of disorder?

a. Bleeding disorder
b. Thrombotic disorder
c. Bruising disorder
d. Hypercalcemia

Question 2

On what does factor VIII depend for stability?

a. VWF
b. Platelets
c. Thrombin
d. Protein S

diana chang · **Reply #1 on:** Jun 25, 2018

Answer to Question 1

ANS: B
Patients with a deficiency of either protein C or protein S have a thrombotic disorder. These two proteins are important in regulating, by downgrading, thrombin generation and thus clotting. Activated protein C binds free protein S to form a complex that inactivates factors Va and VIIIa.

Answer to Question 2

ANS: A
Factor VIII circulates bound to VWF. Free factor VIII is unstable in plasma, so much so that it cannot even be detected.