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Author Question: A 47-year-old man has gingival hypertrophy and a white blood cell (WBC) count of 108 x 109/L. He has ... (Read 83 times)

fagboi

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on: Jun 25, 2018
A 47-year-old man has gingival hypertrophy and a white blood cell (WBC) count of 108 x 109/L. He has a moderate anemia and is thrombocytopenic.
 
  The differential consists primarily of a combination of mature monocytes, promonocytes, and CD14-positive blasts. Which of the following forms of acute myeloid leukemia is most likely?
 
  a. Acute myeloid leukemia with maturation
  b. Acute myeloid leukemia with t(15;17)(q22:q12)
  c. Acute monoblastic leukemia
  d. Acute myeloid leukemia with minimal differentiation

Question 2

The most useful classification system for acute lymphoblastic leukemia based is based on:
 
  a. Immunophenotyping
  b. Morphology
  c. PAS staining
  d. Sudan black B staining


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Jane

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Reply #1 on: Jun 25, 2018
Answer to Question 1

ANS: B
The majority of cells in acute monoblastic leukemia are of monocytic origin, evidenced by being CD14 positive.

Answer to Question 2

ANS: A
Immunophenotyping and genetic analysis are often the only reliable indicator of a cell's origin, and this is the most useful acute lymphoblastic leukemia classification system. Older systems relied primarily on


fagboi

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Reply 2 on: Jun 25, 2018
Thanks for the timely response, appreciate it

bitingbit

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Reply 3 on: Yesterday
Excellent

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