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Author Question: Nuclear hyposegmentation and denser than normal chromatin clumping are features of: a. ... (Read 110 times)

TVarnum

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on: Jun 25, 2018
Nuclear hyposegmentation and denser than normal chromatin clumping are features of:
 
  a. Alder-Reilly anomaly
  b. Chdiak-Higashi syndrome
  c. May-Hegglin anomaly
  d. Pelger-Hut anomaly

Question 2

What are the abnormal cytoplasmic inclusions in Chdiak-Higashi?
 
  a. Nuclear fragments that prevent cell division
  b. Ribosomal material that looks like Dhle bodies
  c. Fused granules that inhibit bactericidal functions
  d. Mucopolysaccharide lipids that disrupt cell function


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hanadaa

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Reply #1 on: Jun 25, 2018
Answer to Question 1

ANS: D
Nuclear hyposegmentation with denser than normal chromatin clumping is found in Pelger-Hut anomaly.

Answer to Question 2

ANS: C
Abnormally large fused granules that are peroxidase positive are seen in Chdiak-Higashi syndrome. Uncontrolled activity of the granular membrane creates large primary, secondary, and mixed primary/secondary granules. These inhibit the normal bactericidal function of these granules so that patients are susceptible to bacterial infection.


TVarnum

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Reply 2 on: Jun 25, 2018
Great answer, keep it coming :)

aliotak

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Reply 3 on: Yesterday
Excellent

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