Nuclear hyposegmentation and denser than normal chromatin ...

[TVarnum]

Nuclear hyposegmentation and denser than normal chromatin clumping are features of:
 
  a. Alder-Reilly anomaly
  b. Chdiak-Higashi syndrome
  c. May-Hegglin anomaly
  d. Pelger-Hut anomaly

Question 2

What are the abnormal cytoplasmic inclusions in Chdiak-Higashi?
 
  a. Nuclear fragments that prevent cell division
  b. Ribosomal material that looks like Dhle bodies
  c. Fused granules that inhibit bactericidal functions
  d. Mucopolysaccharide lipids that disrupt cell function

[hanadaa]

Answer to Question 1

ANS: D
Nuclear hyposegmentation with denser than normal chromatin clumping is found in Pelger-Hut anomaly.

Answer to Question 2

ANS: C
Abnormally large fused granules that are peroxidase positive are seen in Chdiak-Higashi syndrome. Uncontrolled activity of the granular membrane creates large primary, secondary, and mixed primary/secondary granules. These inhibit the normal bactericidal function of these granules so that patients are susceptible to bacterial infection.

[TVarnum]

Excellent

[duy1981999]

Thanks for the timely response, appreciate it