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Author Question: Which of the following is the normal approximate percentage of hemoglobins in adults? a2b2 a2d2 ... (Read 82 times)

plus1

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on: Jun 25, 2018
Which of the following is the normal approximate percentage of hemoglobins in adults?
 
  a2b2 a2d2 a2g2
 
  a. 2 2 96
  b. 2 96 2
  c. 96 2 2
  d. 40 20 40

Question 2

An adult female patient from Southeast Asia has no anemia, but her complete blood count (CBC) shows an MCV of 68 fL and marked target cells are observed on her blood film.
 
  Cellulose acetate alkaline electrophoresis shows two large bands: approximately 55 migrating with Hb A and 40 migrating with Hb C. What is the patient's most
 
  a. Hb A and Hb C
  b. Hb A and Hb E
  c. Hb C and Hb E
  d. Homozygous Hb E


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joechoochoy

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Reply #1 on: Jun 25, 2018
Answer to Question 1

ANS: C
In adults, the approximate concentration of hemoglobin A (Hb A) (a2b2) is 96; of Hb A2 (a2d2), 2; and of hemoglobin F (Hb F) (a2g2), 2.

Answer to Question 2

ANS: B
Hb E is a variant found in Southeast Asian populations. It migrates with Hb C on cellulose acetate alkaline electrophoresis. Because Hb A is also present, this patient probably has Hb E trait (is not homozygous for Hb E). The MCV is low and target cells are present in this trait.


plus1

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Reply 2 on: Jun 25, 2018
Excellent

jackie

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Reply 3 on: Yesterday
Thanks for the timely response, appreciate it

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