Author Question: An increase in the concentration of 2,3-BPG: a. Puts hemoglobin the relaxed conformation form ... (Read 196 times)

luvbio · **on:** Jun 25, 2018

An increase in the concentration of 2,3-BPG:

a. Puts hemoglobin the relaxed conformation form
b. Shifts the oxygen dissociation curve to the left
c. Increases the affinity of hemoglobin for oxygen
d. Is present in patients with severe anemia and decreased blood pH (acidosis)

Question 2

Why is it important that synthesis of globin chains and heme be balanced in the RBCs?

a. Excess concentration of protoporphyrin increases bilirubin in plasma.
b. An excess of one of the components of hemoglobin decreases RBC survival.
c. An excess of one of the components of hemoglobin increases RBC survival leading to an eventual elevated RBC count.
d. An excess of globin chains significantly decreases the concentration of globin chain messenger ribonucleic acid (mRNA) in the developing RBCs.

braelync · **Reply #1 on:** Jun 25, 2018

Answer to Question 1

ANS: D
Patients who are severely anemic and those with a decreased blood pH, among others, have increased levels of 2,3-BPG. This shifts the oxygen dissociation curve to the right, thus deceasing the affinity of hemoglobin for oxygen. The result is more effective delivery of oxygen to tissue. An elevated concentration places the hemoglobin molecule in the tense conformational form.

Answer to Question 2

ANS: B
An excess of one of the components of hemoglobin can decrease RBC survival in circulation. None of the other listed items are true in the presence of an excess.