Give the results (prolonged or normal) for the bleeding time, ...

[ericka1]

Give the results (prolonged or normal) for the bleeding time, prothrombin time, activated partial thromboplastin time, and thrombin time for a patient on prolonged anticoagulant therapy.
 
  What will be an ideal response?

Question 2

List the tests that are commonly utilized in the workup of the following:
 
  a. von Willebrand's disease
  b. Hemophilia A
  c. Factor VIII inhibitor
  d. Bernard-Soulier syndrome
  e. TTP
 
  What will be an ideal response?

[aprice35067]

Answer to Question 1

Answer:
a. BT: Bleeding time assesses primary hemostasis, so prolonged anticoagulant therapy should not affect the BT.
b. PT: If the patient is taking Coumadin, the PT time will be prolonged.
c. APTT: If the patient is on heparin or Coumadin, the APTT will be prolonged.
d. TT: Heparin will almost certainly cause a prolonged TT.

Answer to Question 2

Answer:
von Willebrand's disease: PT, APTT, BT, VWF:Ag, VWF activity (RIPA), platelet count, factor VIII, and VWF multimer analysis
Hemophilia A: PT, APTT, and factor VIII
Factor VIII inhibitor: factor VIII activity, Bethesda titer, and mixing study
Bernard-Soulier syndrome: BT, platelet aggregation studies, and platelet count
TTP: bleeding time, platelet aggregation studies, and platelet count