How does the vascular system contribute to hemostasis? What ...

[saraeharris]

How does the vascular system contribute to hemostasis?
 
  What will be an ideal response?

Question 2

Which of the following acts as a transport portal for granules to move from the organelle zone to the membrane zone?
 
  a. Open canalicular system
  b. Dense tubular system
  c. Membrane glycoproteins
  d. Endoplasmic reticulum

[debra928]

Answer to Question 1

Answer: The vascular system contributes to hemostasis through its various functions:
 Procoagulant
 Anticoagulant
 Fibrinolytic
General characteristics:
 It has the ability to undergo vasoconstriction (procoagulant) and vasodilation (anticoagulant).
 It's layers of the blood vessel (tunica adventitia, tunica media, and tunica intima) all have collagen: exposed subendothelial collagen is responsible for initiating contact activation and platelet adhesion and activation.
 It is a source of von Willebrand factor needed for platelet adhesion and factor VIII carrier
Other procoagulant functions:
 Releases p-selectin to recruit WBC and PLTs to the site of injury
Anticoagulant functions:
 Releases prostacyclin (platelet activator inhibitor and vasodilator)
 Releases nitric oxide (vasodilator)
 Releases thrombomodulin (interacts with thrombin to activate protein C and S pathway that degrades factors V and VIII)

Answer to Question 2

Correct Answer: A

[saraeharris]

TYSM

[sailorcrescent]

Thanks for the timely response, appreciate it