Which of the following is a positive predictive factor in ...

[fagboi]

Which of the following is a positive predictive factor in children with precursor B-ALL?
 
  a. High leukocyte count; less than 1 year of age
  b. Low leukocyte count; 4-10 years of age
  c. High leukocyte count; PBX1/E2A translocation
  d. Hyperdiploid chromosomes, high leukocyte count, less than 1 year of age

Question 2

Name the classifications of ALL, and explain how they differ in molecular analysis and immunophenotype.
 
  What will be an ideal response?

[rleezy04]

Answer to Question 1

Correct Answer: B

Answer to Question 2

Answer: The WHO Classification defines two subgroups of precursor ALL/LBL: Precursor B-cell and precursor T-cell neoplasms (leukemia/lymphoma)

B-cell ALL/LBLs are further subgrouped as ALL with recurrent cytogenetic abnormalities and ALL not otherwise specified (NOS).
Precursor B-cell molecular ID
 1212 t(12;21)(p13;q22.3)/ETV6-RUNX1 1212 t(4;11)(q21;q23)/MLL-AFF1
 1212 t(9;22)(q34;q11)/BCR-ABL1
 1212 t(5;14)(q31;q32.3)/IL3-IGH2
 1212 t(1;19)(q23.3;p13.3)/E2A-PBX1(TCF3-PBX1)
Precursor B-cell immunophenotype: CD19, CD20, CD22, CD79a
Precursor T-cell immunophenotype: TCR, CD3, CD5, CD7 (CD2, CD4, CD8)

[fagboi]

Excellent

[rleezy04]

Gracias!