Author Question: Contrast the clinical and laboratory findings of ALL to LBL. What will be an ideal ... (Read 31 times)

Yolanda · **on:** Jun 25, 2018

Contrast the clinical and laboratory findings of ALL to LBL.

What will be an ideal response?

Question 2

Which markers are found on lymphoblasts?

a. CD10
b. CD19
c. HLA-DR
d. All of the above

jonathanballen97 · **Reply #1 on:** Jun 25, 2018

Answer to Question 1

Answer: Although ALL is primarily a neoplasm of the bone marrow and peripheral blood and LBL is a neoplasm that presents as a solid mass in lymphoid tissue, the two entities are not always distinct. Tissue involvement can occur in ALL, and peripheral blood and bone marrow involvement can occur in LBL. It is thought that ALL and LBL are different clinical expressions of the same disease.
Sites of involvement in B-cell LBL include skin, soft tissue, and lymph nodes. In T-cell LBL, mediastinal (thymic) involvement is common.
T-cell ALL and LBL tend to have more aggressive clinical behavior than B-cell malignancies have. These T-cell malignancies often involve extranodal and extramedullary sites. Lymphadenopathy and hepatospenomegaly are usually present.

Answer to Question 2

Correct Answer: D