A 6-year-old boy was taken to see his pediatrician because of ...

[vicky]

A 6-year-old boy was taken to see his pediatrician because of tiny pinpoint spots that had appeared on his upper torso 3 days earlier. A CBC revealed 70 blasts, and a platelet count of 18 x 109/L.
 
  A bone marrow aspirate and biopsy indicate a diagnosis of ALL.
 
  Which of the following cytochemical stains would be positive in this case?
  a. MPO
  b. LAP
  c. NSE
  d. PAS

Question 2

Patients with acute myelomonocytic leukemia are at higher risk of infection compared with individuals with acute myelocytic leukemia with differentiation.
 
  Explain why there is a higher risk of infection in patients diagnosed with acute myelomonocytic leukemia.
 
  What will be an ideal response?

[ecox1012]

Answer to Question 1

Correct Answer: D

Answer to Question 2

Answer: In patients diagnosed with acute myelomonocytic leukemia, the production of mature monocytes and neutrophils is severely limited (both cell types function to eliminate bacteria). In acute myelocytic leukemia with differentiation, the neutrophil lineage is severely compromised, but there is at least some production of normal monocytes to elicit an antibacterial innate immune response.

[vicky]

TYSM

[amynguyen1221]

Excellent