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Author Question: Which of the following is found to be a factor in TTP? a. Escherichia coli O157:H7 b. Shigella ... (Read 153 times)

sammy

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on: Jun 25, 2018
Which of the following is found to be a factor in TTP?
 
  a. Escherichia coli O157:H7
  b. Shigella species
  c. S. pneumoniae
  d. Shigella dysenteriae serotype I

Question 2

Explain why the DAT profile in CAD is reactive only with polyspecific AHG and anti-C3 but not with anti-IgG.
 
  What will be an ideal response?


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Viet Thy

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Reply #1 on: Jun 25, 2018
Answer to Question 1

Correct Answer: B and C

Answer to Question 2

Answer: The antibody associated with CAD is usually autoanti-I, which is an IgM antibody. In vivo, the antibody attaches in the cooler parts of the body (fingers, toes) and begins to fix complement. As the cells circulate to warmer parts of the body, the antibody dissociates from the cell, leaving only complement. Poly-specific AHG detects IgG and C3 on the RBC, which in this case is positive because of the C3 on the membrane.


sammy

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Reply 2 on: Jun 25, 2018
Thanks for the timely response, appreciate it

mochi09

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Reply 3 on: Yesterday
Excellent

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