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Author Question: Explain why peripheral neuropathy is a common finding in vitamin B12 deficiency. What will be an ... (Read 93 times)

bobbie

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on: Jun 25, 2018
Explain why peripheral neuropathy is a common finding in vitamin B12 deficiency.
 
  What will be an ideal response?

Question 2

Explain how vitamin B12 deficiency can cause folate deficiency.
 
  What will be an ideal response?


k2629

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Reply #1 on: Jun 25, 2018
Answer to Question 1

Answer: In vitamin B12 deficiency, there is a defect in the degradation of propionyl CoA to MM CoA. As a result, propionyl CoA accumulates and replaces succinyl CoA in fatty acid metabolism. This impaired fatty acid metabolism causes demyelination of peripheral neurons.

Answer to Question 2

Answer: Vitamin B12 is needed to convert 5-methyltetrahydrofolate to folate. Consequently, vitamin B12 deficiency can lead to folate deficiency.


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