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Author Question: Nucleated red blood cells in the peripheral blood are a common finding in beta thalassemia patients. ... (Read 25 times)

gonzo233

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on: Jun 25, 2018
Nucleated red blood cells in the peripheral blood are a common finding in beta thalassemia patients. Explain why.
 
  What will be an ideal response?

Question 2

A promoter mutation of a globin chain gene in thalassemia has which effect on the globin chain?
 
  a. Amino acid change
  b. Change to a longer globin chain
  c. Change to a shorter globin chain
  d. Reduced or absent production


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missalyssa26

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Reply #1 on: Jun 25, 2018
Answer to Question 1

Answer: As a result of impaired globin chain synthesis, the bone marrow responds by producing more red blood cells to compensate for the impaired oxygen delivery function. Because of the high BM turnover of erythroblasts, premature release of nucleated erythroblasts is common.

Answer to Question 2

Correct Answer: D


gonzo233

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Reply #2 on: Jun 25, 2018
Thank you :)


missalyssa26

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Reply #3 on: Jun 25, 2018
Happy to help you


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