Author Question: What are three defining characteristics that would help the laboratory professional differentiate ... (Read 41 times)

pane00 · **on:** Jun 25, 2018

What are three defining characteristics that would help the laboratory professional differentiate between a blast and an activated lymphocyte?

What will be an ideal response?

Question 2

What is the difference between polyclonal antibodies and monoclonal antibodies? List examples of disorders that generate each type of antibody in your answer.

What will be an ideal response?

234sdffa · **Reply #1 on:** Jun 25, 2018

Answer to Question 1

Answer: Blasts: high N:C ratio; large cell; open chromatin pattern with prominent nucleoli; scanty basophilic cytoplasm
Activated lymphocyte: Low N:C ratio; large, but may be variable sized cell; more clumped chromatin and oval-shaped nucleus; abundant cytoplasm with basophilic rim; kiss other cells producing a scalloped cell shape

Answer to Question 2

Answer: Polyclonal antibodies are in a group of heterogeneous antibodies with multiple antigenic specificities. Monoclonal antibodies have a single specificity. Multiple myeloma generates monoclonal antibodies; infectious mononucleosis generates polyclonal antibodies.