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Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.
Earwax has antimicrobial properties that reduce the viability of bacteria and fungus in the human ear.
In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
It is believed that the Incas used anesthesia. Evidence supports the theory that shamans chewed cocoa leaves and drilled holes into the heads of patients (letting evil spirits escape), spitting into the wounds they made. The mixture of cocaine, saliva, and resin numbed the site enough to allow hours of drilling.
The familiar sounds of your heart are made by the heart's valves as they open and close.