Author Question: One theory suggests that organ dysfunction in MODS occurs in a sequential or progressive pattern. ... (Read 239 times)

fox · **on:** Jun 25, 2018

One theory suggests that organ dysfunction in MODS occurs in a sequential or progressive pattern. Place the following organs in the order in which they are affected

1 . Bone marrow
2 . Cardiac
3 . Gut
4 . Kidneys
5 . Liver
6 . Lungs

a. 6, 5, 2, 1, 3, 4
b. 5, 4, 6, 1, 2, 3
c. 6, 5, 3, 4, 2, 1
d. 6, 3, 4, 5, 2, 1

Question 2

Profound weight loss in patients with SIRS or MODS is the result of

a. hypometabolism.
b. hypermetabolism.
c. hyperglycemia.
d. intolerance to enteral feedings.

amynguyen1221 · **Reply #1 on:** Jun 25, 2018

Answer to Question 1

C
Organ dysfunction may occur in a sequential or progressive pattern. Organ dysfunction may begin in the lungs, the most commonly affected major organ, and progress to the liver, gut, and kidneys. Cardiac and bone marrow dysfunction may follow. Neurologic and autonomic system impairment may occur and propagate the progression of organ failure, which is associated with illness severity and mortality. Organs may fail simultaneously; for example, kidney dysfunction may occur concurrently with hepatic dysfunction. After the initial insult and resuscitation, patients develop persistent hypermetabolism, a metabolic consequence of sustained systemic inflammation and physiologic stress followed closely by pulmonary dysfunction, manifested as acute respiratory distress syndrome.

Answer to Question 2

B
Hypermetabolism in SIRS or MODS results in profound weight loss, cachexia, and loss of organ function. The goal of nutritional support is the preservation of organ structure and function. Although nutritional support may not definitely alter the course of organ dysfunction, it prevents generalized nutritional deficiencies and preserves gut integrity. Enteral nutrition may exert a physiologic effect that downregulates the systemic immune response and reduces oxidate stress.