Answer to Question 1
There are only two progenitor cells that eventually produce all white cell types: a myeloid stem cell and a lymphoid stem cell. Mutations resulting in leukemia occur within the genes that drive the differentiation or maturation of these two cell lines.
Answer to Question 2
Functional immunoincompetence results from a proliferation of immature or defective cells (incompetent cells) that are not capable of carrying out their normal function. Often, a proliferation of immunoincompetent cells is accompanied by a decreased number of normal, competent cells. The decreased number of normal cells results when the over-proliferation of one cell type outcompetes normal cells for resources (space and nutrients) in the bone marrow.
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