Author Question: Explain this statement in layman's terms: Proliferation of neointima leading to transplantation ... (Read 25 times)

stevenposner

  • Hero Member
  • *****
  • Posts: 608
Explain this statement in layman's terms: Proliferation of neointima leading to transplantation atherosclerosis eventually occludes blood vessels, resulting in patchy ischemia and fibrosis of the graft.
 
  What will be an ideal response?

Question 2

Explain in layman's terms the role of passenger dendritic cells in organ rejection.
 
  What will be an ideal response?



LegendaryAnswers

  • Sr. Member
  • ****
  • Posts: 341
Answer to Question 1

Neointima is a new or thickened layer of cells lining the lumen of arteries. Thickening of this layer causes the lumen to become increasingly narrow over time, restricting the flow of blood and therefore the amount of oxygen that reaches the tissues served by the artery. The chronic lack of oxygen causes the tissue to become scarred in patchy areas throughout the transplanted organ.

Answer to Question 2

Passenger cells are those white cells that are located within the donor organ at the time the organ is transplanted. They are carried within the donated organ and are transplanted into the recipient. These cells are capable of identifying the recipient's tissues as foreign and instigating an immune reaction. Once an immune reaction is started, the recipient's immune system attacks the donated organ, potentially leading to partial or complete rejection (destruction) of the organ.



Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question


 

Did you know?

Multiple experimental evidences have confirmed that at the molecular level, cancer is caused by lesions in cellular DNA.

Did you know?

The largest baby ever born weighed more than 23 pounds but died just 11 hours after his birth in 1879. The largest surviving baby was born in October 2009 in Sumatra, Indonesia, and weighed an astounding 19.2 pounds at birth.

Did you know?

Limit intake of red meat and dairy products made with whole milk. Choose skim milk, low-fat or fat-free dairy products. Limit fried food. Use healthy oils when cooking.

Did you know?

Women are two-thirds more likely than men to develop irritable bowel syndrome. This may be attributable to hormonal changes related to their menstrual cycles.

Did you know?

In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.

For a complete list of videos, visit our video library