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In 1885, the Lloyd Manufacturing Company of Albany, New York, promoted and sold "Cocaine Toothache Drops" at 15 cents per bottle! In 1914, the Harrison Narcotic Act brought the sale and distribution of this drug under federal control.
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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On average, someone in the United States has a stroke about every 40 seconds. This is about 795,000 people per year.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.