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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
According to the FDA, adverse drug events harmed or killed approximately 1,200,000 people in the United States in the year 2015.
Famous people who died from poisoning or drug overdose include, Adolf Hitler, Socrates, Juan Ponce de Leon, Marilyn Monroe, Judy Garland, and John Belushi.
In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
The average office desk has 400 times more bacteria on it than a toilet.