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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
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Human kidneys will clean about 1 million gallons of blood in an average lifetime.
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On average, someone in the United States has a stroke about every 40 seconds. This is about 795,000 people per year.

