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Did you know?
Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
Did you know?
The longest a person has survived after a heart transplant is 24 years.
Did you know?
Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.
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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.