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The B-complex vitamins and vitamin C are not stored in the body and must be replaced each day.
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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About 100 new prescription or over-the-counter drugs come into the U.S. market every year.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.