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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
There used to be a metric calendar, as well as metric clocks. The metric calendar, or "French Republican Calendar" divided the year into 12 months, but each month was divided into three 10-day weeks. Each day had 10 decimal hours. Each hour had 100 decimal minutes. Due to lack of popularity, the metric clocks and calendars were ended in 1795, three years after they had been first marketed.
Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
Cytomegalovirus affects nearly the same amount of newborns every year as Down syndrome.