« previous next »

Author Question: Which pharmacokinetic/pharmacodynamic parameter is least affected by the aging process? a. ... (Read 32 times)

EAugust

  • Hero Member
  • *****
  • Posts: 550
on: Jul 11, 2018
Which pharmacokinetic/pharmacodynamic parameter is least affected by the aging process?
 
  a. Absorption
  b. Distribution
  c. Metabolism
  d. Excretion

Question 2

Factors that affect the pharmacokinetics of lipophilic medications in older include:
 
  a. greater adipose tissue ratio to body mass
  b. decreased total body water
  c. increased glomerular filtration rate
  d. increased creatinine clearance


milbourne11

  • Sr. Member
  • ****
  • Posts: 322
Reply #1 on: Jul 11, 2018
Answer to Question 1

ANS: A
There is no conclusive evidence that the absorptive process is changed appreciably in older adults. Distribution, metabolism, and excretion are all affected significantly by aging.

Answer to Question 2

ANS: A
Older adults have a higher ratio of adipose (fat) tissue where lipophilic (fat soluble) medica-tions can be stored thus resulting in a potential for an accumulation of the medication and potentially fatal overdoses. Older adults have a decrease in lean body mass and an increase in fat. An increased body mass would not affect lipophilic medication absorption. Older adults have a decreased glomerular filtration rate, which begins to decline as early as age 25. Older adults have a decrease in overall kidney function.


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
« previous next »
 

Did you know?

Nearly 31 million adults in America have a total cholesterol level that is more than 240 mg per dL.

Did you know?

Aspirin may benefit 11 different cancers, including those of the colon, pancreas, lungs, prostate, breasts, and leukemia.

Did you know?

A serious new warning has been established for pregnant women against taking ACE inhibitors during pregnancy. In the study, the risk of major birth defects in children whose mothers took ACE inhibitors during the first trimester was nearly three times higher than in children whose mothers didn't take ACE inhibitors. Physicians can prescribe alternative medications for pregnant women who have symptoms of high blood pressure.

Did you know?

Hip fractures are the most serious consequences of osteoporosis. The incidence of hip fractures increases with each decade among patients in their 60s to patients in their 90s for both women and men of all populations. Men and women older than 80 years of age show the highest incidence of hip fractures.

Did you know?

Inotropic therapy does not have a role in the treatment of most heart failure patients. These drugs can make patients feel and function better but usually do not lengthen the predicted length of their lives.

Glioma. (a) Illustration of a large glioma (colored area) within the left cerebral hemisphere in a s Glioma. (a) Illustration of a large glioma (colored area) within the left cerebral hemisphere in a s
Small nuclear RNAs (snRNA), 100-200 bp in length, form part of the splicing mechanisms to process mR Small nuclear RNAs (snRNA), 100-200 bp in length, form part of the splicing mechanisms to process mR
Physiological and evolutionary theories of aging. Physiological and evolutionary theories of aging.
Lattice Parameter Relationships and Figures Showing Unit Cell Geometries for the Seven Crystal Syste Lattice Parameter Relationships and Figures Showing Unit Cell Geometries for the Seven Crystal Syste
The Drug Development Process The Drug Development Process
If the random variable x is exponentially distributed with parameter λ = 4, then P(x ≤ ... If the random variable x is exponentially distributed with parameter λ = 4, then P(x ≤ ...
Video: Cardiac conductile cells

For a complete list of videos, visit our video library