Which pharmacokinetic/pharmacodynamic parameter is least affected ...

[EAugust]

Which pharmacokinetic/pharmacodynamic parameter is least affected by the aging process?
 
  a. Absorption
  b. Distribution
  c. Metabolism
  d. Excretion

Question 2

Factors that affect the pharmacokinetics of lipophilic medications in older include:
 
  a. greater adipose tissue ratio to body mass
  b. decreased total body water
  c. increased glomerular filtration rate
  d. increased creatinine clearance

[milbourne11]

Answer to Question 1

ANS: A
There is no conclusive evidence that the absorptive process is changed appreciably in older adults. Distribution, metabolism, and excretion are all affected significantly by aging.

Answer to Question 2

ANS: A
Older adults have a higher ratio of adipose (fat) tissue where lipophilic (fat soluble) medica-tions can be stored thus resulting in a potential for an accumulation of the medication and potentially fatal overdoses. Older adults have a decrease in lean body mass and an increase in fat. An increased body mass would not affect lipophilic medication absorption. Older adults have a decreased glomerular filtration rate, which begins to decline as early as age 25. Older adults have a decrease in overall kidney function.