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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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Medication errors are more common among seriously ill patients than with those with minor conditions.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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It is believed that humans initially contracted crabs from gorillas about 3 million years ago from either sleeping in gorilla nests or eating the apes.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.