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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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The modern decimal position system was the invention of the Hindus (around 800 AD), involving the placing of numerals to indicate their value (units, tens, hundreds, and so on).
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Excessive alcohol use costs the country approximately $235 billion every year.