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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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People about to have surgery must tell their health care providers about all supplements they take.
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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
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Sperm cells are so tiny that 400 to 500 million (400,000,000–500,000,000) of them fit onto 1 tsp.
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In 1864, the first barbiturate (barbituric acid) was synthesized.